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Public release date: 9-Jan-2013
Share ] Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, report on a small peptide that blocked antibody recognition of desmogleins. Importantly, the peptide could prevent antibody-mediated skin blistering when applied topically to mice. At the cellular level, the peptide improved cell-cell adhesion and attenuated signaling pathways that are activated by antibody binding. These results suggest that this peptide could serve as a treatment option for pemphigus vulgaris.
TITLE:
Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering
AUTHOR CONTACT:
Jens Waschke
Ludwig-Maximilians-University Munich, Munich, , DEU
Phone: 0049-89-5160-4811; Fax: 0049-89-5160-4802; E-mail: jens.waschke@med.uni-muenchen.de
View this article at: http://www.jci.org/articles/view/60139?key=b333192372ea9937c9be
A new treatment for kidney disease-associated heart failure?
Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein klotho (klotho hypomorphic mice) also develop vascular calcification and have shorter life spans compared to normal mice. In this issue of the Journal of Clinical Investigation, Florian Lang and colleagues at the University of Tbingen in Germany, found that treatment with the mineralocorticoid receptor antagonist spironolactone reduced vascular calcification in klotho hypomorphic mice and increased their life span. In a companion Attending Physician article, Darryl Quarles of the University of Tennessee discusses the implications of these findings for the treatment of CKD patients.
TITLE:
Spironolactone-sensitive vascular calcification and Pit-1-dependent osteoblastic differentiation in klotho-hypomorphic mice
AUTHOR CONTACT:
Florian Lang
Dept. of Physiology, Tuebingen, NULL, DEU
Phone: +4970712972194; Fax: +497071295618; E-mail: florian.lang@uni-tuebingen.de
View this article at: http://www.jci.org/articles/view/64093?key=3010c850d2f970ad6617
ACCOMPANYING THE ATTENDING PHYSICIAN
TITLE:
Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new
AUTHOR CONTACT:
Darryl Quarles
University of Tennessee Health Science Center, memphis, TN, USA
Phone: 901-448-1459; Fax: 901-448-1188; E-mail: dquarles@uthsc.edu
View this article at: http://www.jci.org/articles/view/67203?key=054ae63743c930253936
New fusion gene contributes to glioblastoma progression
Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice. In this issue of the Journal of Clinical Investigation, researchers led by Matti Annala at Tampere University of Technology in Finland identified a fusion between the FGFR3 and TACC3 genes in human glioblastoma samples. The protein produced by this fusion gene promoted tumor growth and progression in a mouse model of glioblastoma, while increased expression of either of the normal genes did not alter tumor progression. Ivan Babic and Paul Mischel of the University of California, San Diego, explain in the accompanying commentary that it remains unclear how this fusion protein mediates tumorigenesis.
TITLE:
The tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma
AUTHOR CONTACT:
Matti Annala
Tampere University of Technology, Tampere, FIN
Phone: +358415079885; E-mail: matti.annala@tut.fi
View this article at: http://www.jci.org/articles/view/67144?key=b644a26bcc8a516cd41d
ACCOMPANYING COMMENTARY
TITLE:
Multiple functions of a glioblastoma fusion oncogene
AUTHOR CONTACT:
Paul Mischel
UCSD, La Jolla, CA, USA
Phone: (858) 534-6080; Fax: ; E-mail: pmischel@ucsd.edu
View this article at: http://www.jci.org/articles/view/67658?key=0186fce1cd2ddde6082f
ALSO IN THIS ISSUE
TITLE:
Type 1 diabetes patients exhibit altered cerebral metabolism during hypoglycemia
AUTHOR CONTACT:
Bastiaan de Galan
Radboud University Nijmegen Medical Centre, Nijmegen, UNK, NLD
Phone: +31243618819; Fax: +31243541734; E-mail: b.degalan@aig.umcn.nl
View this article at: http://www.jci.org/articles/view/62742?key=9b86666385df6bd2593b
TITLE:
Regulation of dendritic cell activation by microRNA let-7c and BLIMP1
AUTHOR CONTACT:
Betty Diamond
The Feinstein Institute for Medical Research, Manhasset, NY, USA
Phone: 516-562-3830; Fax: 516-562-2953; E-mail: bdiamond@nshs.edu
View this article at: http://www.jci.org/articles/view/64712?key=6599e97537112226049c
TITLE:
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer
AUTHOR CONTACT:
Yosuke Osawa
Gifu University Graduate School of Medicine, Gifu, JPN
Phone: 81-58-230-6217; Fax: 81-58-230-6218; E-mail: osawa-gif@umin.ac.jp
View this article at: http://www.jci.org/articles/view/65188?key=4dc45a19d2e16fb3b7c9
TITLE:
Specialized role of migratory dendritic cells in peripheral tolerance induction
AUTHOR CONTACT:
Juliana Idoyaga
The Rockefeller University, New York, NY, USA
Phone: 212-327-7863; Fax: 212-327-8875; E-mail: ijuliana@rockefeller.edu
View this article at: http://www.jci.org/articles/view/65260?key=843f605de298ce5048b3
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 9-Jan-2013 Share ] Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, report on a small peptide that blocked antibody recognition of desmogleins. Importantly, the peptide could prevent antibody-mediated skin blistering when applied topically to mice. At the cellular level, the peptide improved cell-cell adhesion and attenuated signaling pathways that are activated by antibody binding. These results suggest that this peptide could serve as a treatment option for pemphigus vulgaris.
TITLE:
Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering
AUTHOR CONTACT:
Jens Waschke
Ludwig-Maximilians-University Munich, Munich, , DEU
Phone: 0049-89-5160-4811; Fax: 0049-89-5160-4802; E-mail: jens.waschke@med.uni-muenchen.de
View this article at: http://www.jci.org/articles/view/60139?key=b333192372ea9937c9be
A new treatment for kidney disease-associated heart failure?
Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein klotho (klotho hypomorphic mice) also develop vascular calcification and have shorter life spans compared to normal mice. In this issue of the Journal of Clinical Investigation, Florian Lang and colleagues at the University of Tbingen in Germany, found that treatment with the mineralocorticoid receptor antagonist spironolactone reduced vascular calcification in klotho hypomorphic mice and increased their life span. In a companion Attending Physician article, Darryl Quarles of the University of Tennessee discusses the implications of these findings for the treatment of CKD patients.
TITLE:
Spironolactone-sensitive vascular calcification and Pit-1-dependent osteoblastic differentiation in klotho-hypomorphic mice
AUTHOR CONTACT:
Florian Lang
Dept. of Physiology, Tuebingen, NULL, DEU
Phone: +4970712972194; Fax: +497071295618; E-mail: florian.lang@uni-tuebingen.de
View this article at: http://www.jci.org/articles/view/64093?key=3010c850d2f970ad6617
ACCOMPANYING THE ATTENDING PHYSICIAN
TITLE:
Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new
AUTHOR CONTACT:
Darryl Quarles
University of Tennessee Health Science Center, memphis, TN, USA
Phone: 901-448-1459; Fax: 901-448-1188; E-mail: dquarles@uthsc.edu
View this article at: http://www.jci.org/articles/view/67203?key=054ae63743c930253936
New fusion gene contributes to glioblastoma progression
Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice. In this issue of the Journal of Clinical Investigation, researchers led by Matti Annala at Tampere University of Technology in Finland identified a fusion between the FGFR3 and TACC3 genes in human glioblastoma samples. The protein produced by this fusion gene promoted tumor growth and progression in a mouse model of glioblastoma, while increased expression of either of the normal genes did not alter tumor progression. Ivan Babic and Paul Mischel of the University of California, San Diego, explain in the accompanying commentary that it remains unclear how this fusion protein mediates tumorigenesis.
TITLE:
The tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma
AUTHOR CONTACT:
Matti Annala
Tampere University of Technology, Tampere, FIN
Phone: +358415079885; E-mail: matti.annala@tut.fi
View this article at: http://www.jci.org/articles/view/67144?key=b644a26bcc8a516cd41d
ACCOMPANYING COMMENTARY
TITLE:
Multiple functions of a glioblastoma fusion oncogene
AUTHOR CONTACT:
Paul Mischel
UCSD, La Jolla, CA, USA
Phone: (858) 534-6080; Fax: ; E-mail: pmischel@ucsd.edu
View this article at: http://www.jci.org/articles/view/67658?key=0186fce1cd2ddde6082f
ALSO IN THIS ISSUE
TITLE:
Type 1 diabetes patients exhibit altered cerebral metabolism during hypoglycemia
AUTHOR CONTACT:
Bastiaan de Galan
Radboud University Nijmegen Medical Centre, Nijmegen, UNK, NLD
Phone: +31243618819; Fax: +31243541734; E-mail: b.degalan@aig.umcn.nl
View this article at: http://www.jci.org/articles/view/62742?key=9b86666385df6bd2593b
TITLE:
Regulation of dendritic cell activation by microRNA let-7c and BLIMP1
AUTHOR CONTACT:
Betty Diamond
The Feinstein Institute for Medical Research, Manhasset, NY, USA
Phone: 516-562-3830; Fax: 516-562-2953; E-mail: bdiamond@nshs.edu
View this article at: http://www.jci.org/articles/view/64712?key=6599e97537112226049c
TITLE:
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer
AUTHOR CONTACT:
Yosuke Osawa
Gifu University Graduate School of Medicine, Gifu, JPN
Phone: 81-58-230-6217; Fax: 81-58-230-6218; E-mail: osawa-gif@umin.ac.jp
View this article at: http://www.jci.org/articles/view/65188?key=4dc45a19d2e16fb3b7c9
TITLE:
Specialized role of migratory dendritic cells in peripheral tolerance induction
AUTHOR CONTACT:
Juliana Idoyaga
The Rockefeller University, New York, NY, USA
Phone: 212-327-7863; Fax: 212-327-8875; E-mail: ijuliana@rockefeller.edu
View this article at: http://www.jci.org/articles/view/65260?key=843f605de298ce5048b3
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-01/joci-jet010213.php
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Daunting wildfires continue in the Australian state of New South Wales, but the consuming inferno that officials had feared does not fully materialize. Still, officials warn that the danger is not over and that hot conditions have moved further north. On Tuesday, Australia recorded its highest average temperature yet: 104.59 degrees Fahrenheit. [CNN]
The worst winter storm in two decades hits the eastern Mediterranean, bringing destruction and death to Syria and its neighbors even as the region deals with a refugee crisis related to the Syrian civil war. [Reuters]
Noble Energy is pursuing plans to drill for oil and natural gas across a 40,000-acre swath of public and private land near Wells, Nev., about 400 miles north of Las Vegas. The project would mark the first use of hydraulic fracturing in Nevada. [The Las Vegas Review-Journal]
A look at ?frackademia,? or how energy companies are sponsoring research on fracking at some of the nation?s leading universities, including several in Pennsylvania, a font of natural gas drilling. [The Guardian]
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LONDON (AP) ? Top business executives have warned U.K. Prime Minister David Cameron that he could damage Britain's economy if he seeks to renegotiate the terms of its membership in the 27-country European Union.
In a letter published in the Financial Times on Wednesday, Virgin Group's Richard Branson, London Stock Exchange head Chris Gibson-Smith and eight other business leaders challenged Cameron's plan to renegotiate the U.K.'s EU membership terms and put the matter to a referendum.
The executives warned that such a plan could fail, pushing the U.K. out of the EU and hurting business in the process.
Membership in the EU has given the U.K. access to the massive European market as well as a say in how the region should govern itself and run its financial markets. The country has also benefited from EU funds to build infrastructure such as broadband networks.
However, popular distrust of the EU has grown in Britain ? one of the 10 countries in the region that doesn't use the euro. The British public shows no interest in the EU's plans to move closer together. Most can't even seem to stomach the current level of power of the EU, which many Britons see as meddlesome and inefficient.
Though the business leaders urged EU reform in their letter, they argued "we must be very careful not to call for a wholesale renegotiation of our EU membership, which would almost certainly be rejected."
"To call for such a move in these circumstances would be to put our membership of the EU at risk and create damaging uncertainty for British business, which are the last things the prime minister would want to do," they said.
A senior U.S. official also expressed concern about the prospect of a referendum, saying the Obama administration wants to see a "strong British voice" in the EU.
Philip Gordon, the U.S. assistant secretary for European affairs, told reporters in London that "referendums have often turned countries inward" ? but stressed that whatever is in the U.K.'s interest is up to the U.K.
"We welcome an outward-looking EU with Britain in it," he said.
Tough economic times are forcing the 17 EU countries that use the euro to move ever closer, creating a more powerful union that could leave non-euro members like Britain with less negotiating power.
But while Cameron wants Britain to remain in the EU and to retain influence in the body, he is also resisting a push by many member states, like France and Germany, to grant central authorities in Brussels greater powers over financial and legal affairs for the whole of the EU. In the long run, many EU countries want to turn the bloc into a United States of Europe, an idea British politicians, particularly among Cameron's Conservatives, abhor.
Cameron is due to make a speech in mid-January to outline his position and the requests he will make. On Wednesday, he told lawmakers that Britain could get the changes it wanted.
"We're active players in the European Union but there are changes we would like in our relationship that would be good for Britain and good for Europe and I think, because of the changes in eurozone which is driving a lot of change in the European Union, there's every opportunity to achieve that settlement and seek consent for it," he said.
Source: http://news.yahoo.com/business-leaders-warn-uk-pm-against-leaving-eu-141106929--finance.html
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Skullcandy hasn't made any official headphone-related announcements at CES -- but that doesn't mean there isn't news to share. We've just been tipped about a bass-pumping followup to its non-defunct Skullcrusher headphones, set to release as the Crusher. The circumaural cans are said to be designed and engineered in-house, though they do look similar to Logitech UE's over-ears. As we understand it, the so-called "crushing sensation" is handled by a vibrating unit inside of each earcup that's independent from its actual 40mm speaker drivers. Impressively, we're told that the lowend will still pump out if the battery dies unlike similar offerings, such as Sony's Pulse gaming headset. An on-earcup control lets you dial in your preferred level of wub, and the earcups can collapse for storage. Naturally, a detachable 3.5mm cable with an inline remote / mic is also included. Expect these to hit shelves during March clad in your choice of black, white or red for a cool 100 bones. That's all we've got for now, so keep it locked to our coverage of the show while we try to spot 'em ourselves.
Filed under: Peripherals, Portable Audio/Video, Wearables
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/6C6Snh-Kvy0/
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This topic is an Out Of Character part of the roleplay, ?Sleeping Era?. Anything posted here will also show up there.Topic Tags:
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iHeartRadio isn't limiting its CES announcements to mobile and PC wares. The internet streaming service is heading to Chrysler Uconnect and 2014 GM infotainment systems. Soon, the company's library of 1,500 channels will be available in-dash with mobile app compatibility for further fine-tuning with Chrysler's Uconnect Access software on Android and iOS handsets. In addition to the manufacturer news, iHeartRadio has also teamed up with Clear Channel Media and Entertainment to bring the iHeartAuto app for aftermarket vehicle gadgets. This software will allow standardized tools for devs and easy implementation for manufacturers. As of today, support for Clarion Smart Access, Pioneer's AppRadio platform and Kenwood's DNN990HD receiver is now available. For a bit more info on both of the happenings, take a look at the full PR that resides below.
Filed under: Transportation, Software
Source: http://www.engadget.com/2013/01/07/iheartradio-chrysler-gm-iheartauto-app/
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Therefore, the analog phone to build a lot of communication towers to protect the signal (as PHS with the same). At present, the analog network is already closed. Here to mention that the analog phones is just a historical retrospective. Enable readers to understand the rapid advances in communications technology. The electric energy consumption of the GPS cell phone jammer is 0.5W/h.
Digital mobile phone. Digital mobile phone currently the mainstream use of digital mobile phones (2rd Generation, Mobile, 2G), the transfer process is a digit string of numbers 0 and 1, different combinations to represent sounds, so that less sound distortion, signal strength, the communications tower significantly fewer. Digital mobile phone standard mainly refers to the cellular Global System for Mobile communication system, the GSM 2G (Global System for Mobile communication) and code division multiple access the CDMA (Code Division Multiple Access). Digital cellular phone of the most widely used is the European GSM standard operators as China Mobile and China Unicom. The GPS cell phone jammer can effectively and strongly work on all equipments of GPS signals.
The CDMA standard in the United States, China Unicom is also operational, there is a certain group of users. Both phones provide voice and SMS services, and data transmission services to a certain extent. 3.3G mobile phone. The third-generation digital communication phone, referred to as 3G mobile phones (3rd Generation, Mobile, 3G) will become a mainstream product. Generally refers to the combination of a new generation of mobile multimedia communications such as wireless communication and Internet communication system for mobile phones. The third generation mobile phone apart from the second generation of mobile phone features, but also be able to listen to mobile music, watching mobile TV, including web browsing, conference calls, e-commerce and other functions. At present, the international 3G mobile phone, there are three kinds of standard criteria. This high tech product of GPS cell phone jammer is very popular and well received.
WCDMA for GSM Evolution (of WCDMA Wireless, CDMA wireless CDMA) standard; CDMA evolution after the CDMA2000 standard; and our self-developed TD-SCDMA (Time Division-Synchronous the CDMA Time Division Synchronous Code Division Multiple Access) standard. 2.1.3 2.1.3 according to the structural characteristics of sub-bar phone is Nokia to create European style; flip phone is the shape of the trend of Japan and South Korea Cell Phone Jammers; slim phone is a new trend led by companies such as Europe and the United States Apple. The ultra-thin mobile phone made thin and light form a user?s needs, is easy to carry and use. The slim phone is a difficult challenge to the structural design and process technology. It is the high power cell phone jammer with external cooling device.
Also have the opportunity to play a technical expertise to the structural designer. Hungarian design company Design House Egy Studio designed the concept of mobile phone Auro only 6mm thickness. Figure 2-1 (b) Auro only 6mm thickness, large 3.9-inch touch screen and control buttons (direction lever control, call off, then confirm the key) with a new design, combined with the virtual numeric keys put this bar up adjustment. The Auro prototype default specifications, including HSDPA, WiFi, Bluetooth 2.0, unlimited transfer and extrapolation 2GB/4GB microSD memory card, use the Windows Mobile 5 (or 6) operating system, is comparable to the iPhone mobile phone. This machine is still in the design phase, is expected to be listed in 2008. This kind of high power cell phone jammer is widely used in the large area.
Source: http://www.celljammerchina.com/this-high-tech-product-of-gps-cell-phone-jammer-is-very-popular/
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Source: http://benjamin737.posterous.com/this-high-tech-product-of-gps-cell-phone-jamm
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SINGAPORE/HONG KONG????Call it phablet, phonelet, tweener or super smartphone, but the clunky mobile phone???closer in size to a tablet than the smartphone of a couple of years back???is here to stay.
A surprise hit of 2012, it is drawing in more users, more handset makers and is shaping the way we consume content.
"We expect 2013 to be the year of the phablet," said Neil Mawston, UK-based executive director of Strategy Analytics' global wireless practice.
While Samsung has blazed a trail with its once-mocked Galaxy Note devices, now other manufacturers are scurrying to catch up.
At this week's Consumer Electronics Show in Las Vegas, Chinese telecommunications giants ZTE and Huawei Technologies Co (HTC) will launch their own.
ZTE, which collaborated with Italy's designer Stefano Giovannoni for the Nubia phablet, is scheduled to launch its 5-inch Grand S, while Huawei brings out the Ascend Mate, sporting a whopping 6.1-inch screen, making it only slightly smaller than Amazon's Kindle Fire tablet.?
"Users have realised that a nearly 5-inch screen smartphone isn't such a cumbersome device," said Joshua Flood, senior analyst at ABI Research in Britain.
Driving the phablet's shift to the mainstream is a confluence of trends. Users prefer larger screens because they are consuming more visual content on mobile devices than before, and using them less for voice calls - the phablet's weak spot.
And as Wi-Fi-only tablets become more popular, so has interest among commuters in devices that combine the best of both, while on the move.
According to the latest Ericsson Mobility Report, the monthly data traffic for every smartphone will rise fourfold between now and 2018 to 1,900 megabytes.
The upshot is a market for phablets that will quadruple in value to $135 billion in three years, according to Barclays. Shipments of gadgets that are 5 inches or bigger in screen size will surge by nearly nine-fold to 228 million during the same period, though estimates vary because no one can agree on where smartphones stop and phablets start.
But that's the point, some say.
"I think phone size was a preconceived notion based on voice usage," said John Berns, a Singapore-based executive who works in the information technology industry. He recently upgraded his Note for the newer Note 2 and bought another for his girlfriend for Christmas. "Smaller was better until phones got smart, became visual."
Samsung has been both the engine and beneficiary. While other players shipped devices with larger screens earlier???Dell launched its Streak in 2010???it was only when the Korean behemoth launched the Galaxy Note in late 2011, with its 5.3-inch screen, that users took an interest.
"The Streak was launched at a time when 3-inch smartphones were standard and the leap to a 5-inch Streak was a jump too far for consumers," says Strategy Analytics' Mawston.
"The Galaxy Note was launched when 4-inch smartphones had become commonplace, and the leap to 5-inch was no longer such a chasm."?
The bigger, the better
Since then Samsung has bet big on bigger: its updated Note has a 5.5-inch screen and its flagship Galaxy S3???the best-selling smartphone in the third quarter of 2012 - has a screen that puts it in the phablet category for some analysts.
Samsung accounted for around three quarters of all phablets shipped last year, according to Barclays' Taipei-based analyst Dale Gai.
Samsung's marketing heft has paved the way for others. LG Electronics Inc accounted for 14 percent of shipments in the third quarter of last year, according to Strategy Analytics.
HTC Corp's 5-inch Butterfly???called the Droid DNA in the United States???has been selling well in places where Samsung is less dominant, according to Taipei-based Yuanta Securities analyst Dennis Chan. The first batch sold out soon after its December launch in Taiwan.
"I don't think we can say that Samsung invented phablets," said Lv Qianhao, head of handset strategy at ZTE. "But it did do a lot to promote this product category, which helped create tremendous demand."
Phablets are also proving popular in emerging markets.
A poll of nearly 5,000 readers of Yahoo's Indonesian website chose Samsung's Galaxy Note 2 as their favourite mobile phone of 2012, ahead of the iPhone 5.
Kristian Tjahjono, a technology journalist who posted the poll, said phablets were a natural fit for Indonesians who liked tablets but also liked making phone calls.
But while those in such markets who can afford them are going for the high-end devices, the door is opening for cheaper models. Tjahjono pointed to Lenovo's 5-inch S880, which has a lower resolution screen and sells for about $250, which is around a third of the price of Galaxy Note 2.?
Sweet spot
Falling component prices will add to demand. The total cost of an upper-end phablet, its bill of materials, will likely fall to 2,000 yuan ($323) this year, says Gai from Barclays, and will halve within two years.
"One thousand yuan is a very sweet spot for China," he said.
India is also a fan.
Vivek Deshpande, who manages global strategy for Shenzhen-based mobile phone maker Zopo, says that while the Indian and Chinese markets are different, they both share a common appetite for aspirational devices: phones big enough for their owners to show off. This is changing the direction of lower end players.
"Zopo's primary focus is now on phablets," said Deshpande.
Even Samsung is pushing its own creation downmarket: In Las Vegas it will unveil the Galaxy Grand, a 5-inch device that lacks some of the resolution and muscle of its bigger brethren but will be aimed at markets like India. There is a version offering a dual SIM slot, a popular feature for those wanting to arbitrage cheaper call and data plans.
As phablets slide into the mainstream, handset makers are trying to find ways of differentiating.
As well as hiring Italian designer Giovannoni better known for his minimalist, sleek bathrooms, ZTE also came up with an onscreen keypad that inclines to one side of the screen, depending on whether the user is left- or right-handed.
Samsung, however, not only has first mover advantage, it can also build on its expertise in display.
Barclay's Gai says Samsung is expected to introduce a thinner, unbreakable AMOLED screen which will leave room for bigger batteries.
"That will put Samsung in good stead to still dominate the market," he said. Despite pressure in China, Gai estimates Samsung's share of smartphones with 5-inch or larger screens to fall only from 73 percent in 2012 to 58 percent in 2016, which is still the lion's share.
By then consumers will see the phablet for what it is, says Horace Dediu, a Finnish analyst who runs a technology blog asymco.com. Its rise is part of a wider march of computing power into wherever we reside???the living room, the train, bed or work.
"It makes sense that we're moving towards a time where we are served not by a computer or a netbook or a phone, but rather that we have these screens scattered around and available for us to play with," he said. "In a way the phablet is not a bulky phone but a very delicate computer."?
(c) Copyright Thomson Reuters 2013. Check for restrictions at:?http://about.reuters.com/fulllegal.asp?
Source: http://www.nbcnews.com/technology/gadgetbox/phone-makers-scurry-get-out-their-own-phablets-1B7832678
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Every member of a company's CES lineup can't be a blockbuster -- that's certainly the case with this duo of mid-range Canon PowerShots. The A2600 and A1400 are fine point-and-shoots, sure, but they're destined for the bags of beginner shooters, with modest feature sets and price points to match. The A2600, which replaces last year's A2400, is the pricer of the two models, ringing in at $150 with a 16-megapixel CCD sensor, a 5x 28mm zoom lens with a maximum aperture range of f/2.8-6.9, along with a 3-inch, 230k-dot LCD. It can shoot 720p HD video and includes a Smart Auto mode for basic users, along with a new Eco mode, which dims the display after two seconds, powers it off completely after eight seconds, and jumps back to life with a single button press -- all in the name of an up to 30-percent boost in battery life.
The $100 A1400 looks nearly identical to 2012's A1300, but adds in the imaging and power features outlined above. Spec-wise, the biggest difference between the A1400 and A2600 is the substitution of twin AA batteries for the latter camera's rechargeable cell. While manufacturers often boast about the flexibility of an AA-powered camera, considering that you can purchase these batteries anywhere on the globe, such a solution ultimately cuts back on Canon's expenses while potentially becoming quite pricey and inconvenient for the camera's owner. So, don't forget to factor in those double-As when it comes time to pull the trigger. Both PowerShot models are expected to hit stores next month, with the A2600 retailing for $150 and the A1400 running you about 100 bucks.
Source: http://www.engadget.com/2013/01/07/canon-powershot-a2600-a1400/
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Jan. 7, 2013 ? In 2011, a months-long blast of energy launched by an enormous black hole almost 11 billion years ago swept past Earth. Using a combination of data from NASA's Fermi Gamma-ray Space Telescope and the National Science Foundation's Very Long Baseline Array (VLBA), the world's largest radio telescope, astronomers have zeroed in on the source of this ancient outburst.
Theorists expect gamma-ray outbursts occur only in close proximity to a galaxy's central black hole, the powerhouse ultimately responsible for the activity. A few rare observations suggested this is not the case.
The 2011 flares from a galaxy known as 4C +71.07 now give astronomers the clearest and most distant evidence that the theory still needs some work. The gamma-ray emission originated about 70 light-years away from the galaxy's central black hole.
The 4C +71.07 galaxy was discovered as a source of strong radio emission in the 1960s. NASA's Compton Gamma-Ray Observatory, which operated in the 1990s, detected high-energy flares, but the galaxy was quiet during Fermi's first two and a half years in orbit.
In early November 2011, at the height of the outburst, the galaxy was more than 10,000 times brighter than the combined luminosity of all of the stars in our Milky Way galaxy.
"This renewed activity came after a long slumber, and that's important because it allows us to explicitly link the gamma-ray flares to the rising emission observed by radio telescopes," said David Thompson, a Fermi deputy project scientist at NASA's Goddard Space Flight Center in Greenbelt, Md.
Located in the constellation Ursa Major, 4C +71.07 is so far away that its light takes 10.6 billion years to reach Earth. Astronomers are seeing this galaxy as it existed when the universe was less than one-fourth of its present age.
At the galaxy's core lies a supersized black hole weighing 2.6 billion times the sun's mass. Some of the matter falling toward the black hole becomes accelerated outward at almost the speed of light, creating dual particle jets blasting in opposite directions. One jet happens to point almost directly toward Earth. This characteristic makes 4C +71.07 a blazar, a classification that includes some of the brightest gamma-ray sources in the sky.
Boston University astronomers Alan Marscher and Svetlana Jorstad routinely monitor 4C +71.07 along with dozens of other blazars using several facilities, including the VLBA.
The instrument's 10 radio telescopes span North America, from Hawaii to St. Croix in the U.S. Virgin Islands, and possess the resolving power of a single radio dish more than 5,300 miles across when their signals are combined. As a result, The VLBA resolves detail about a million times smaller than Fermi's Large Area Telescope (LAT) and 1,000 times smaller than NASA's Hubble Space Telescope.
In autumn 2011, the VLBA images revealed a bright knot that appeared to move outward at a speed 20 times faster than light.
"Although this apparent speed was an illusion caused by actual motion almost directly toward us at 99.87 percent the speed of light, this knot was the key to determining the location where the gamma-rays were produced in the black hole's jet," said Marscher, who presented the findings Monday at the American Astronomical Society meeting in Long Beach, Calif.
The knot passed through a bright stationary feature of the jet, which the astronomers refer to as its radio "core," on April 9, 2011. This occurred within days of Fermi's detection of renewed gamma-ray flaring in the blazar. Marscher and Jorstad noted that the blazar brightened at visible wavelengths in step with the higher-energy emission.
During the most intense period of flaring, from October 2011 to January 2012, the scientists found the polarization direction of the blazar's visible light rotated in the same manner as radio emissions from the knot. They concluded the knot was responsible for the visible and the gamma-ray light, which varied in sync.
This association allowed the researchers to pinpoint the location of the gamma-ray outburst to about 70 light-years from the black hole.
The astronomers think that the gamma rays were produced when electrons moving near the speed of light within the jet collided with visible and infrared light originating outside of the jet. Such a collision can kick the light up to much higher energies, a process known as inverse-Compton scattering.
The source of the lower-energy light is unclear at the moment. The researchers speculate the source may be an outer, slow-moving sheath that surrounds the jet. Nicholas MacDonald, a graduate student at Boston University, is investigating how the gamma-ray brightness should change in this scenario to compare with observations.
"The VLBA is the only instrument that can bring us images from so near the edge of a young supermassive black hole, and Fermi's LAT is the only instrument that can see the highest-energy light from the galaxy's jet," said Jorstad.
NASA's Fermi Gamma-ray Space Telescope is an astrophysics and particle physics partnership. Fermi is managed by NASA's Goddard Space Flight Center. It was developed in collaboration with the U.S. Department of Energy, with contributions from academic institutions and partners in France, Germany, Italy, Japan, Sweden and the United States.
The VLBA is operated by the National Radio Astronomy Observatory, a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.
For images related to this finding and to learn more about Fermi, visit: http://go.nasa.gov/TGwz3N
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/space_time/astronomy/~3/VWYA2QZIjsI/130107175006.htm
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As the job market becomes increasingly competitive, it can be difficult to hold on to valuable employees. Read about how team building can play a big role in effective employee retention.
One of the newest challenges facing human resources departments in the 21st century is employee retention. As it becomes increasingly easier for business professionals to network within the corporate sphere, through social media, seminars, conventions, and other new channels, there are now many more opportunities for employees ? your employees ? to find a ?better? job.
?Better? can mean a lot of things for a lot of different employees: better-paying, more engaging, better opportunity for advancement, or better opportunities. regardless of why an employee might potentially leave your company, it is a scary and unpredictable reality that few HR departments want to deal with. After all, companies invest a great deal into its employees ? no one ever wants to lose talent and productivity, and start from scratch with an unknown, new employee.
Team building is one way that businesses can avoid losing valuable employees.
We?ve written about it before on this blog about the delicate balance that exists between fostering a team atmosphere in your office workplace and the need to understand and listen to your employees. While managers and business owners dream of having a workforce that is artistically motivated to succeed on behalf of their team and business, the reality is more complex: an employee?s work has to be rewarding, they need to feel essential to the success of a team, and they need to feel that their pay is commensurate with the work and results they provide.
Team building can help in reinforcing an employee?s sense of connection to their team. Team building events such as Team Apprentice help to recreate an employee?s role in the success of a team in a fun, different setting, while still remaining in the domain of business. Not only does the event itself help to reinforce the importance that each individual plays in making a team a success, but also it demonstrates to a workforce a company?s willingness to invest in their employees: because team building is generally a fun experience and a diversion from the everyday work experience, it resonates with employees.
Often times, employees lose sight of their importance in the business processes that they work within. Or, sometimes employees realise their importance, but feel that their management fails to recognise how important they are to the team. Use team building events to show your employees how much you care about their role in the success of the company.
Tags: employee retention
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With few exceptions, the world of developers (and startups in general), is really known for its scandals. But when Ruby icon Why the Luck Stuff (also known simply as _why) suddenly took all of his projects offline - including the famous Why's (poignant) Guide to Ruby - offline in August 2009, there was quite a bit of uproar and anger in the programming community. _why had always guarded his anonymity closely, but nobody expected him to just abandon his projects and disappear into the night.Source: http://feedproxy.google.com/~r/Techcrunch/~3/2ojWlYsaSQ8/
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FILE - This July 23, 2010, file photo shows Gen. Stanley McChrystal reviewing troops for the last time as he is honored at a retirement ceremony at Fort McNair in Washington. Speaking out for the first time since he resigned, retired Gen. Stanley McChrystal writes in a new memoir that he takes the blame for the Rolling Stone article that ended his Afghan command and army career, including for the unflattering comments attributed to his staff about the Obama administration. (AP Photo/J. Scott Applewhite, file)
FILE - This July 23, 2010, file photo shows Gen. Stanley McChrystal reviewing troops for the last time as he is honored at a retirement ceremony at Fort McNair in Washington. Speaking out for the first time since he resigned, retired Gen. Stanley McChrystal writes in a new memoir that he takes the blame for the Rolling Stone article that ended his Afghan command and army career, including for the unflattering comments attributed to his staff about the Obama administration. (AP Photo/J. Scott Applewhite, file)
WASHINGTON (AP) ? Speaking out for the first time since he resigned, retired Gen. Stanley McChrystal takes the blame for a Rolling Stone article and the unflattering comments attributed to his staff about the Obama administration that ended his Afghanistan command and army career.
"Regardless of how I judged the story for fairness or accuracy, responsibility was mine," McChrystal writes in his new memoir, in a carefully worded denouncement of the story.
The Rolling Stone article anonymously quoted McChrystal's aides as criticizing Obama's team, including Vice President Joe Biden. Biden had disagreed with McChrystal's strategy that called for more troops in Afghanistan. Biden preferred to send a smaller counterterrorism and training force ? a policy the White House is now considering as it transitions troops from the Afghan war.
McChrystal adds the choice to resign as U.S. commander in Afghanistan was his own.
"I called no one for advice," he writes in "My Share of the Task," describing his hasty plane ride back to Washington only hours after the article appeared in 2010, to offer his resignation to President Barack Obama. McChrystal was immediately replaced by his then-boss, Gen. David Petraeus.
McChrystal devotes a scant page-and-a-half to the incident that ended his 34-year military career and soured trust between the military and media. The book, published by Portfolio/Penguin, an imprint of Penguin Group USA, comes out Monday.
The closest McChrystal comes to revealing his regret over allowing a reporter weeks of unfettered access with few ground rules comes much earlier in the book. "By nature I tended to trust people and was typically open and transparent. ... But such transparency would go astray when others saw us out of context or when I gave trust to those few who were unworthy of it."
McChrystal does try to explain the tensions that helped lead to Obama's decision to accept his resignation. At the center was the wrangle over McChrystal's recommendation for 40,000 more U.S. troops in Afghanistan ? and conflicting guidance.
Defense Secretary Robert Gates told McChrystal to request the number he thought he needed. White House staff signaled that the newly election president wanted to keep the levels down.
McChrystal describes how he presented his war goal to the White House as "defeat the Taliban" and "secure the population," and was advised to lower his sights to "degrade" the Taliban.
Obama approved the addition of 30,000 troops, while simultaneously announcing a withdrawal date of 2014. McChrystal did not challenge those decisions, though he says he worried the timetable would embolden the Taliban.
"If I felt like the decision to set a withdrawal date would have been fatal to the success of our mission, I'd have said so," he writes.
As for the Rolling Stone fallout, a Pentagon inquiry into the magazine's profile cleared McChrystal of wrongdoing and called into question the accuracy of the June 2010 story. The review, released in April 2011, concluded that not all of the events at issue happened as reported in the article.
Rolling Stone issued a statement saying it stood behind freelance writer Michael Hastings' story, which it called "accurate in every detail."
There is no bitterness or score-settling with the White House staff that had pushed for his departure over the article. McChrystal and the White House moved beyond the matter, and first lady Michelle Obama invited McChrystal to serve on the board of Joining Forces, a White House initiative for troops and their families.
The book details the general's rise through the ranks, from his time as a West Point cadet to serving in the 82nd Airborne Corps and earning his Special Forces Green Beret, and then commanding a battalion of the 75th Ranger regiment.
McChrystal describes only briefly an incident that nearly ended his career years earlier: allegations of a cover-up involving the friendly fire incident that killed football-star-turned-Army Ranger Pat Tillman. McChrystal approved a Silver Star for valor, with a citation that stated Tillman had been cut down by "devastating enemy fire."
But as reports came in from the troops at the scene, McChrystal realized Tillman may have died by fratricide. He sent an oblique warning to his superiors that President George W. Bush should delete mention of enemy fire from his remarks, when presenting the award to Tillman's family at his memorial service.
McChrystal told the investigators that he believed Tillman deserved the award, and that he wanted to warn top U.S. military and political leadership that friendly fire was a possibility. The Pentagon later cleared him of wrongdoing.
In the book, McChrystal writes only that he followed "standard practice" to quickly process a Silver Star for Tillman's actions on the battlefield, in time to present it to the family at the memorial service. He explains he had become aware before Tillman's memorial service that friendly fire was likely the cause of death, and sent notice to his superiors that was classified secret, as all his communications were. McChrystal writes that left the decision of what to pass on to the White House to his superiors.
The man portrayed in the Rolling Stone article as arrogant comes off as far more down to earth in the book.
McChrystal writes of his doubts when he was asked to take charge of the military's top counterterrorism unit, the Joint Special Operations Command. He worried the troops would reject him because he had not served in any of its elite units such as the Army's Delta Force or the Navy's SEAL Team 6.
He says he helped JSOC evolve from a disconnected organization that was slow to catch targets early on in Iraq, because the operators lacked the manpower or communications equipment to analyze intelligence they gathered quickly enough. It eventually grew into closely networked teams that worked with the CIA and FBI and others to take down up to a dozen targets a night in Afghanistan, with intelligence gathered from the first target leading to the others.
At the request of Pentagon security reviewers, the former general made famous by his command at JSOC doesn't use that term, instead substituting "Task Force 714" for JSOC, "Green team" for Delta, and "Blue" for SEAL Team 6.
Those are part of the changes the general agreed to make, because those units and their missions are classified, according to two U.S. officials briefed on the security review. They spoke anonymously because they were not authorized to speak to the media.
The review process delayed the release of the book, which had been scheduled to come out in December. Pentagon officials decided to give the book another read, after a member of the Navy SEAL team that killed Osama bin Laden released an account of the raid without submitting the manuscript for a security review.
McChrystal said he "accepted many suggested changes and redactions, some reluctantly, particularly where public knowledge of facts and events has outpaced existing security guidelines," in order to "keep faith with the comrades I had served alongside."
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Rescue workers aboard a snowmobile recover the bodies of six people who died following a sled crash on Mount Cermis, northern Italy, early Saturday, Jan. 5, 2013. Six Russians were killed and two others were injured after their snowmobile slammed into a fence and flipped over into a ditch during a night run down an Italian ski slope. The Russian consul general in Milan, Alexei Parmonov, said on Russian state television that he was in contact with Italian investigators, who he said suspect the crash was caused by excessive speed. They also were checking the possibility of a mechanical malfunction. (AP Photo/Federico Modica)
Rescue workers aboard a snowmobile recover the bodies of six people who died following a sled crash on Mount Cermis, northern Italy, early Saturday, Jan. 5, 2013. Six Russians were killed and two others were injured after their snowmobile slammed into a fence and flipped over into a ditch during a night run down an Italian ski slope. The Russian consul general in Milan, Alexei Parmonov, said on Russian state television that he was in contact with Italian investigators, who he said suspect the crash was caused by excessive speed. They also were checking the possibility of a mechanical malfunction. (AP Photo/Federico Modica)
Rescue workers recover the bodies of six people who died following a sled crash on Mount Cermis, northern Italy, early Saturday, Jan. 5, 2013. Six Russians were killed and two others were injured late Friday after their snowmobile slammed into a fence and flipped over into a ditch during a night run down an Italian ski slope. The Russian consul general in Milan, Alexei Parmonov, said on Russian state television that he was in contact with Italian investigators, who he said suspect the crash was caused by excessive speed. They also were checking the possibility of a mechanical malfunction. In 1998, a U.S. Marine jet, flying low on a training run from a nearby air base, accidently sliced a ski gondola's cable on Mount Cermis, sending the cable car crashing to the ground and claiming 20 lives. (AP Photo/Federico Modica)
Red Cross personnel stand in the area where six people died following a sled crash on Mount Cermis, northern Italy, early Saturday, Jan. 5, 2013. Six Russians were killed and two others were injured after their snowmobile slammed into a fence and flipped over into a ditch during a night run down an Italian ski slope. The Russian consul general in Milan, Alexei Parmonov, said on Russian state television that he was in contact with Italian investigators, who he said suspect the crash was caused by excessive speed. They also were checking the possibility of a mechanical malfunction. (AP Photo/Federico Modica)
Italian alpine rescue workers on a snowmobile recover the bodies of six people who died following a sled crash on Mount Cermis, northern Italy, early Saturday, Jan. 5, 2013. Six Russians were killed and two others were injured after their snowmobile slammed into a fence and flipped over into a ditch during a night run down an Italian ski slope. The Russian consul general in Milan, Alexei Parmonov, said on Russian state television that he was in contact with Italian investigators, who he said suspect the crash was caused by excessive speed. They also were checking the possibility of a mechanical malfunction. (AP Photo/Federico Modica)
Members of the Italian alpine rescue team recover the bodies of six people died following a sled crash on Mount Cermis, northern Italy, early Saturday, Jan. 5, 2013. Six Russians were killed and two others were injured after their snowmobile slammed into a fence and flipped over into a ditch during a night run down an Italian ski slope. The Russian consul general in Milan, Alexei Parmonov, said on Russian state television that he was in contact with Italian investigators, who he said suspect the crash was caused by excessive speed. They also were checking the possibility of a mechanical malfunction. (AP Photo/Federico Modica)
ROME (AP) ? Six Russians were killed and two seriously injured when the snowmobile and sled they were riding veered off an Italian Alpine ski slope at night, slammed into a barrier and flew through the air into a ravine.
The accident occurred Friday night and when rescuers arrived at the scene six of the victims were found dead on the slope of Mount Cermis, in the Trentino-Alto Adige region of northeast Italy, said Cavalese Fire Department Cmdr. Roberto Marchi.
"It is clear that the fundamental cause is recklessness and imprudence," Marchi told Sky TG24 TV in an interview on the slope Saturday. It is labeled "pista nera" or black ski run, indicating a level of steepness and other difficult conditions suitable only for the most experienced skiers.
Six of the people involved in the accident were Russian tourists and the other two were Russians who worked in Italy in the tourist industry.
Cavalese Mayor Silvano Welponer said that putting a driver and passenger in the snowmobile and having it pull six passengers in the sled "made for a very heavy load. You have to know what you are doing and have the experience" to safely handle that, he said.
The ANSA news agency said authorities were performing tests to determine if the snowmobile's driver ? who survived the crash ? was drunk.
The sled-towing snowmobile cut a spectacular trajectory after it veered off the slope on a curve, hit the manmade barrier, flew through the air while shearing the tips off tree branches, then landed in the ravine, Italian news reports said.
RAI state radio said the slope was unlit, and other Italian news reports quoted local officials as saying it had been closed for the day and that the only vehicles allowed on it when it is open are staff or rescue ones. The Russians were believed to have dined at the top of the slopes and were heading back to their hotel when they crashed, the reports said.
The Russian consul general in Milan, Alexei Parmonov, said on Russian state television that he was in contact with Italian investigators, who he said suspect the crash was caused by excessive speed. They also were checking the possibility of a mechanical malfunction.
Italian prosecutors formally opened a probe to see if manslaughter charges should be filed, Italian news reports said.
Parmonov identified the four men and two women who died in the crash. Five of them and also one of the injured men were tourists from Krasnodar, a region in southern Russia that includes Sochi, which is preparing to hold the 2014 Winter Olympics. One of the dead women and the other injured man worked in Italy in the tourist industry.
The Russian diplomat identified the dead as Denis Kravchenko, Irina Kravchenko, Vyacheslav Sleptsov, Yulia Yudina, Lyudmila Yudina and Rafilya Pshenichnaya. The injured, he said, were Boris Yudin and Azat Agafarov. All except Pshenichnaya and Agafarov were tourists from Krasnodar. Yudin's 17-year-old son, who stayed behind in the hotel, lost his mother and sister in the accident, while his father was hospitalized with multiple fractures, Parmonov said.
A day of entertainment had been planned for the Val di Fiemme ski resort area Saturday, ahead of World Cup cross-country ski competition, but the festivities were canceled because of the accident.
Mount Cermis suffered two deadly accidents in the past.
In 1998, a U.S. Marine jet, flying low on a training run from a nearby air base, accidently sliced a ski gondola's cable, sending the cable car crashing to the ground and claiming 20 lives. The accident triggered months of tensions between Italy and the United States, two traditional good allies.
In 1976, a ski gondola broke off from its cable and plunged to the slope, killing 42 persons.
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